AKT1 and infection: Consequently, SAG continued to drive Akt phosphorylation (Fig 8B), which in turn augmented the nuclear translocation and the binding of Runx proteins to the CD40 promoter (Figs 8C and Fig 8D; S15B, left two panels) and thereby increased CD40 expression on BMDCs despite LD infection (Figs 8A and S15A).