The results showed no significant differences in host IRF1 attenuation following IFN-γ stimulation (Fig 4C) or in host cell EZH2 induction when comparing PruQ or TgPPM3C-HA, ΔTgPPM3C, and TgPPM3C-COMP infections (Fig 4D), providing further evidence that the export of only certain MYR1-dependant effector proteins (GRA16 and GRA28) appears to be impaired in the ΔTgPPM3C strain. This evidence concerns the gene IRF1 and infection.