A number of interesting target genes were highlighted during the microarray analysis in SKOV-3 cells following knockdown of TLR4 associated with metastasis, angiogenesis, EMT/differentiation and circulating tumour cell (CTC) biology including CD44, HER2, PI3K, MMP13, members of the claudin, cadherin, integrin and laminin family and various olfactory receptors (ORs). This evidence concerns the gene MMP13 and neoplasm.