Several recombinant proteins such as 7-kDa protein, CsEF-1α, 28-kDa cysteine protease, and 26-kDa and 28-kDa glutathione S-transferases of C. sinensis have shown relatively higher specificity than the C. sinensis crude extracts or ESPs for the serodiagnosis of clonorchiasis, but not sufficient sensitivity [17,33]. This evidence concerns the gene HPGDS and clonorchiasis.