For further assay (CRC patients: n = 9, healthy donors: n = 5), when autologous mMDSCs were co-cultured with pan-T cells at a ratio of 1:1 (mMDSCs:pan-T cells), IFN-γ production of pan-T-cells was decreased in 4 out of 5 healthy donors and 8 out of 9 CRC patients, confirming mMDSCs’ suppressive function irrespective of disease state (Fig 4B; Table 2). Here, IFNG is linked to colorectal carcinoma.