PTGDR and familial dilated cardiomyopathy: Limitation to this study: Although, we could show that COX inhibition and more specifically inhibition of the PGD2 receptor DP2 prevents the enhanced white adipocyte formation of CPC in failure prone CKO male hearts, we have not performed chronic treatment with COX inhibitors or BAY-u 3405 to test whether they would have an impact on age-related heart failure of the DCM phenotype.