TANs recruited to the TME respond to CAF secreted IL-6 (Figure 1), as shown in both gastric cancer and HCC, which drives STAT3 and PD-L1 expression, allowing neutrophils to inhibit T cell function (Cheng et al., 2018; Zhu et al., 2014). The gene discussed is STAT3; the disease is hepatocellular carcinoma.