As a result, depleting this population is thought to be an effective way to disrupt the desmoplasia and thus enhance immune infiltration, while either leaving tumor suppressing populations of fibroblasts undisturbed, or also resulting in depletion of such populations, but with the anti-tumorigenic depletion of the FAP+ cells proving dominant (Wang et al., 2014; Lo et al., 2015). This evidence concerns the gene FAP and neoplasm.