CD8A and neoplasm: On one side, TH17 cells can recruit CD8+ T cells to the TME helping to drive antitumor immune response (Martin-Orozco et al., 2009); on the other, IL-17 released from TH17 cells can in turn, drive production of angiogenic factors from fibroblasts and cancer cells (Numasaki, 2003), thus fueling tumor growth.