However, no differences in TB‐induced extrinsic apoptosis could be detected between control and USP22 KO HT‐29 cells (Figs 1B and D, and EV1B, C, E, Appendix Fig S1), suggesting that USP22 specifically regulates necroptosis without affecting TNFα‐dependent pro‐survival or apoptotic cell death. This evidence concerns the gene TNF and tuberculosis.