Apart from enhancing transcriptional regulation, USP22 controls additional biological processes, like cell growth and differentiation, tumor development, and cell death (Zhang et al, 2008b; Lv et al, 2011; Lin et al, 2012; Xu et al, 2012; Li et al, 2013; Sussman et al, 2013). This evidence concerns the gene USP22 and neoplasm.