VNP with shielded version of Art v 1 were hypoallergenic as shown by reduced degranulation of rat basophil leukemia cells sensitized with Art v 1-specific mouse VNP with shielded version of Art v 1 increased Foxp3+ Treg in lungs and cytokines were shifted towards Th1/Treg profile Surface exposed VNP-induced allergen-specific antibodies in mice. The gene discussed is FOXP3; the disease is acute basophilic leukemia.