Results: The single nucleotide polymorphism (SNP), DNMT3B -283T/C, revealed a higher risk of head and neck squamous cell carcinoma (HNSCC) when compared with the C group in the codominant (p< 0.001), dominant (p<0.001), and overdominant (p= 0.001) models for T/C and C/C genotypes. This evidence concerns the gene DNMT3B and head and neck squamous cell carcinoma.