Association of the DNMT3B (-149C/T, -283T/C, -579G/T), DHFR 19-pb ins/del, SHMT1 1420C/T, and TYMS 28-bp Tandem Repeat Polymorphisms with Tumor, Nodes, and Metastasis (TNM) Staging System in Patients with Head and Neck Cancer. The gene discussed is DHFR; the disease is head and neck cancer.