Another systematic evaluation of cancer risk demonstrated that DNMT3B -149C/T, DNMT3B -283T/C, and DNMT3B -579G/T polymorphisms were observed as protective factors against cancer in the Asian population (Duan et al., 2015); however, in our study, the DNMT3B -149C/T and -579G/T SNPs did not contribute to the risk of head and neck cancer, whereas DNMT3B -283T/C might be a risk factor for head and neck carcinogenesis. The gene discussed is DNMT3B; the disease is cancer.