The role of TYMS 28-bp tandem repeat polymorphisms was not associated with acute lymphoblastic leukemia and lung cancer risk development (Oosterom et al., 2018; Stanisławska-Sachadyn et al. 2019); however, a study in the Brazilian population revealed increased risk association between the 2R/2R and 2R/3R variants in sporadic and hereditary breast cancer development, which was not in accordance with the results of our study (da Silva Nogueira et al., 2012). The gene discussed is TYMS; the disease is breast carcinoma.