The univariate analysis conducted on potential risk factors of HCC in our work indicated that both AFP and T allele of SNP rs 738791 in homozygous and heterozygous forms (CT+TT) was associated significantly (p<0.05) with the increased risk of HCC against controls (OR=1.940, 95% CI: 1.514 – 2.486, p<0.001; OR=1.792, 95% CI: 1.112 – 2.887, p<0.017). This evidence concerns the gene AFP and hepatocellular carcinoma.