However, PCDH20 methylation was not associated with the clinicopatho-logical features in NFC (Chen et al., 2015), but was associated with the clinical outcome in severe lung cancer, indicating that the inactivation of PCDH20 could occur regardless of the stage of cancer and that malignancy progression may be involved in this fact (Imoto et al., 2006). The gene discussed is PCDH20; the disease is lung carcinoma.