Role of microRNA profile on protein level in CRC screened and indicated negative correlation of hsa-miR-148a-3p and hsa-miR-192-5p with FN1, a positive correlation of hsa-miR-223-3p and CHEK1, and a positive correlation of hsa-miR-155-5p and CASP7 as the most important microRNAs regulatory modules in CRC regulome, (Figure 6a and supplementary file 6). Here, CHEK1 is linked to colorectal carcinoma.