Finally, considering the correlation results between point mutations and protein levels in CRC, TP53-missense has a positive correlation with TP53 level, PTEN-All mutations have a positive correlation with WWTR1, ACVR2A-all mutations have a positive correlation with CASP7, and ACVR2A-all mutations have a positive correlation with RAD51, (Figure 6e and supplementary file 10). The gene discussed is ACVR2A; the disease is colorectal carcinoma.