IKZF1 and neoplasm: Previous studies have identified numerous deletions in signaling pathways of precursor B-cell (BCP) differentiation (IKZF1, ETV6, PAX5, and EBF1), cell cycle control, tumor suppression (CDKN2A/2B, BTG1, and RB1), and cytokine receptors (CRLF2, IL3RA, CSF2RA, and SHOX) localized in the pseudoautosomal region (PAR1) (Kuiper et al., 2007; Mullighan et al., 2007).