Besides, we showed the importance of co-occurrence between PAX5 or CDKN2A/2B and PAR1 region and between ETV6, BTG1 and IKZF1. The clinical impact of alterations in RB1, BTG1 and ETV6 genes in childhood ALL have not yet been fully appreciated by other researchers (Moorman et al., 2010; Moorman et al., 2012; Schwab et al., 2013). Here, RB1 is linked to acute lymphoblastic leukemia.