LRRK2 and Parkinson disease: For instance, and in contrast to our results, decreased lamin B levels are found in brains from AD (Frost et al, 2016) and PD patients bearing the LRRK2 (G2019S) mutation (Liu et al, 2012), and in aged primary human fibroblasts (Freund et al, 2012) and keratinocytes (Dreesen et al, 2013), being a marker of cellular senescence.