LMNA and Huntington disease: Therefore, here we sought to deeply characterize the impact of lamin alterations in HD brain at physiological (studying nuclear lamina morphology and nucleocytoplasmic transport), transcriptomic (by generating RNA‐sequencing (RNA‐seq) data), and epigenetic (analyzing lamin chromatin binding and chromatin accessibility) levels by using the R6/1 transgenic mouse model of HD and human post‐mortem brain samples.