Since cortical pyramidal neuronal project to the striatum and betulinic acid normalized lamin B1 levels in the cortex, we speculate that the improvement of cortical neuronal function could have beneficial effects on MSNs, reflected by the prevention in the decrease in DARPP‐32 protein levels, a hallmark of HD (Bibb et al, 2000), and consequently, motor performance is partially improved. This evidence concerns the gene LMNB1 and Huntington disease.