The Ikaros family of TFs (including Aiolos) plays important roles in lymphocyte biology, and Aiolos has been incriminated in B cell disorders (hyperproliferative states, autoantibody production, and lymphomas), T cell proliferation, Th17 cell differentiation, and innate immune cell plasticity (27, 28, 29). Here, IKZF3 is linked to lymphoma.