ICOS and neoplasm: Indeed, genes involved in T cell costimulation (il2ra, il2rb, il2rg, cd40lg, icos, cd80), activation via signaling through the TCR (cd8a, cd3z, zap70, ctsw), and tumor killing (gzmb, gzmk, ifng, klrc1, klrk1) were consistently upregulated after 7 and 10 weeks of treatment.