Recent genetic and epigenetic studies using genome‐wide association study (GWAS) and epigenome‐wide association study have found that a number of genes are altered in DKD, including genomic DNA polymorphisms of collagen type IV alpha 3 chain (COL4A3, rs55703767),3 TGF‐β1( rs1800470), TNF‐α(rs1800629), IL‐6 (rs1800797) and IL‐1β (rs16944).4, 5, 6. The gene discussed is COL4A3; the disease is diabetic kidney disease.