TGFB1 and obesity due to melanocortin 4 receptor deficiency: TGF‐β1 can be induced by many mediators of DKD, such as high glucose concentration, reactive oxygen species, advanced glycation end products, activated protein kinase C, renin‐angiotensin II‐aldosterone system components and endothelin,8, 9, 10 and are associated with the development of obesity and diabetes.11, 12