LDLR and hyperlipidemia: In order to verify whether similar behaviour exists also at the physiological level, we investigated whether combined HG and hyperlipidaemia‐induced ED in vivo by using LDL knockout mice CByJ.129S7(B6)‐Ldlrtm1Her/J (LDLR−/−) subjected to hyperlipidaemia, by high‐fat diet and hyperglycaemia, by inducing DM.