Concerning the high levels of NO2 + NO3, most likely this elevation does not reflect enhanced activity of eNOS, rather may stim from activation of iNOS, since combined atherosclerosis and diabetes, as the case in diabetic LDLR−/− mice that were placed on high‐fat diet, is characterized by inflammation manifested by cytokines secretion and induction of iNOS.31, 32. The gene discussed is LDLR; the disease is diabetes mellitus.