Previous studies have shown that acute lipopolysaccharide (LPS) injection 30 min prior to stroke, modeling a low level of peripheral inflammation present in various comorbid conditions, aggravates ischemia‐induced cell death (McColl et al., 2007) and behavioral impairment (Doll et al., 2015) and is associated with increased IL‐1‐mediated neutrophil infiltration, increased blood–brain barrier (BBB) permeability, and mitochondrial dysfunction (Doll et al., 2015; McColl et al., 2007). This evidence concerns the gene IL1B and Stroke.