Given that senile plaque is a main hallmark of AD, levels of senile plaque and Aβ plaque (including Aβ37, Aβ38, Aβ39, Aβ40, and Aβ42) in CA1 region of hippocampus of APP/PS1 mice were detected by Thioflavin S staining and immunofluorescence assay. Here, APP is linked to Alzheimer disease.