Another study investigating common DNA methylation changes across several neurodegenerative diseases25 has suggested shared changes in HIP1 (Alzheimer's disease and Down Syndrome) and MOBP (PD and dementia with Lewy bodies), supporting the notion that DNA methylation changes in these genes can have a broader relevance for neurodegenerative diseases. This evidence concerns the gene MOBP and early-onset autosomal dominant Alzheimer disease.