For CpG sites in HIP1, we observed a total of 10.3% (7/68 CpGs) showing an opposite correlation signal between MSA and healthy controls (r ≥ |0.40|, e.g. cg03437706 MSA r = −0.48 vs. control r = 0.72; and cg27409251 MSA r = −0.69 vs. control r = 0.61; Figure 2; Table S2). The gene discussed is HIP1; the disease is multiple system atrophy.