By investigating loci that have shown significant DNA methylation alterations in multiple system atrophy (MSA), this study identified myelin‐associated oligodendrocyte basic protein (MOBP) and huntingtin interacting protein 1 (HIP1) as new constituents of glial cytoplasmic inclusions (highlighted by arrowheads in b and d) and α‐synuclein interactors, thus strengthening the potential role of these two loci in MSA pathogenesis. This evidence concerns the gene HIP1 and multiple system atrophy.