To test the significance of this finding, we computed the correlation coefficients in MSA and healthy controls in 1000 random genes and found that the number of genes with the number of opposite correlations equal or larger than the 10.3% of CpG sites was much lower than the 5% cut‐off (p = 0.019), showing that the observations for HIP1 are not likely to be due to chance. The gene discussed is HIP1; the disease is multiple system atrophy.