TLR8 and infection: Human TLR8 is predominantly expressed on the endosomal membrane of monocytes, macrophages, conventional dendritic cells (cDCs), and CD4+ regulatory T cells (TREG), and allows cells to respond to infection through detection of viral single‐stranded RNA.(14, 15, 16) GS‐9688 (selgantolimod) is an oral selective small‐molecule agonist of TLR8 in development for CHB.