Besides, ECM proteins may form a barrier preventing the drug availability to the cancer cells, and some protein constituents of our PDSs as fibronectins, collagens and laminins have earlier been linked to cell adhesion‐mediated drug resistance (Landberg et al., 2020; Meads et al., 2009; Senthebane et al., 2017). The gene discussed is LAMB2; the disease is cancer.