Artavanis-Tsakonas et al. in their paper hypothesize that the reason why children who are undergoing their first infection with malaria are less likely to develop cerebral malaria, compared to older children who have already been exposed a couple of times is because, in the latter group, cross-reactive primed T-cells are still being developed, and in the midst of the ‘practice’, they produce copious amounts of IFN-γ, as compared to their younger counterparts20. The gene discussed is IFNG; the disease is malaria.