Among these TR macrophages, some cells displayed exclusively expressed proreparative genes, Cd163 and Mrc1 (Figures 3B,C), while lacking H2-Aa compared to others, suggesting that these cells assume more anti-inflammatory roles during ischemic injuries rather than antigen processing and presentation, consistent with other single-cell sequencing research on cardiac hypertrophy models (25). Here, CD163 is linked to cardiac hypertrophy.