Growing evidence revealed that the ErbB and PI3K–Akt signaling pathways play vital roles in colorectal cancer by regulating microRNA, lncRNA, mRNA, etc. (Szmida et al., 2015; Song et al., 2018; Wei et al., 2019; Zhong et al., 2019; Wan et al., 2020). Here, EGFR is linked to colorectal cancer.