FN1 and medical procedure: Xie et al. (41) showed that inhibiting FN1-SRC proto-oncogene, non-receptor tyrosine kinase/protein tyrosine kinase 2-guanosine triphosphatase (GTPase) signaling could inhibit CC metastasis, and Cai et al. (42) reported that FN1 depletion could inhibit colorectal carcinogenesis by suppressing proliferation, migration, and invasion.