GJA1 and asthma: Further evidence for Cx43 in TNT development in lung injury comes from reports showing that Cx43 is upregulated in mouse lungs during asthma and that overexpression of Cx43 in therapeutically administered iPSC-MSCs restores mitochondrial membrane potential, decreases excess mucus secretion, and reduces inflammatory cells and cytokines caused by lung injury (Yao et al., 2015, 2018).