As shown in Figure 5, thrombin mediated-PAR1 activation signals through PI3K/AKT/mTORC1 and activates Hypoxia-Inducible Factor-1 alpha (HIF-1α) (193), a well-known mediator of tumor survival, EMT, angiogenesis, and metastasis (193–195). This evidence concerns the gene HIF1A and neoplasm.