CXCL8 and cancer: The proteolytic cleavage of PARs activates numerous downstream signaling pathways, including intracellular Ca2+ mobilization, ERK1/2, NFκB signaling pathways and the induction of cytokines such as Interleukin-8 (IL-8) and IL-6 (14), allowing the PARs to mediate several processes in the coagulation-inflammation interplay, including those implicated in cancer progression (15, 16).