HTN, hypertension; DM, diabetes mellitus; COPD, chronic obstructive pulmonary disease; CKI, chronic kidney disease; CAD, coronary artery disease; CVA, cerebrovascular accident; OSA, Obstructive sleep apnea; ACE/ARB, angiotensin converting enzyme/angiotensin II receptor blocker; NSAID, nonsteroidal anti-inflammatory drug. This evidence concerns the gene ACE and Hypertension.