There are also no studies on a functional link between EECs and IgE-mediated food allergy, however, lower numbers of EECs have been associated with irritable bowel syndrome (IBS) patients with food hyper-sensitivities, and dietary intervention studies to remove food triggers and reduce symptoms induce a normalization in Chromogranin A-positive EECs in colonic biopsies of IBS compared to healthy controls (44–46). Here, IGHE is linked to irritable bowel syndrome.