The enhanced secretion of IL-10 was observed in both APS-2 cohorts compared to HC [IL1β/1,25(OH)2D3 AD/AIT vs HC p = 0.004; IL1β/1,25(OH)2D3 T1D/AIT vs HC p = 0.02]. The gene discussed is IL1B; the disease is autoimmune polyendocrinopathy.