The expression of the VDR and CYP27B1 was induced by IL1β and inhibited after administration of 1,25(OH)2D3 in both APS-2 and HC (Figures 2A, B) [VDR: AD/AITIL1β vs IL1β/1,25(OH)2D3 p = 10-4; T1D/AITIL1β vs IL1β/1,25(OH)2D3 p = 2x10-4; HCIL1β vs IL1β/1,25(OH)2D3 p = 2x10-4; CYP27B1: AD/AITIL1β vs IL1β/1,25(OH)2D3 p = 6x10-5; T1D/AITIL1β vs IL1β/1,25(OH)2D3 p = 10-4; HCIL1β vs IL1β/1,25(OH)2D3 p < 10-7]. The gene discussed is IL1B; the disease is type 1 diabetes mellitus.