Group-wise comparisons between APS-2 and HC revealed increased, but not significantly enhanced IL-6 protein in T1D/AIT patients after co-stimulation with IL1β/1,25(OH)2D3 [IL1β/1,25(OH)2D3 T1D/AIT vs HC p = 0.1] and significantly increased IL-6 protein in AD/AIT patients after IL1β/1,25(OH)2D3-co-stimulation [IL1β/1,25(OH)2D3 T1D/AIT vs HC p = 0.02]. Here, IL1B is linked to autoimmune polyendocrinopathy.