The strong induction of CYP24A1 by 1,25(OH)2D3 is observed in both APS-2 cohorts, however less than in HC [IL1β/1,25(OH)2D3 AD/AIT vs HC p = 0.001, IL1β/1,25(OH)2D3 T1D/AIT vs HC p = 0.008] (Figure 2C). Here, CYP24A1 is linked to autoimmune polyendocrinopathy.