APS-2 patients have an increased expression of inflammatory cytokines which is pronounced for the CCL-2 expression that strongly differs between T1D/AIT patients and controls: increased levels are found for CCL-2 in IL1β/1,25(OH)2D3-costimulation [RNA: IL1β/1,25(OH)2D3 T1D/AIT vs HC p = 0.01]. This evidence concerns the gene CCL2 and type 1 diabetes mellitus.