Similarly, several studies demonstrated that the development of neuroinflammation post-traumatic brain injury, ventilator-induced lung injury, diabetic periodontitis, DSS-induced ulcerative colitis, and endometritis in cattle display a significant correlation with NEK7-involved NLRP3 inflammasome activation (Chen Y. et al., 2019; Kelly et al., 2019; Liu et al., 2019; Liu H. et al., 2020; Zhou et al., 2019, 2020; Cao et al., 2020). Here, NLRP3 is linked to endometritis.