Findings from a small non-randomized study of 21 subjects with class New York Heart Association class III/IV heart failure and LVEF ≤ 40%, demonstrated that a 5-week GLP-1 infusion (2.5 pmol/kg/min) improved LVEF and 6-min treadmill walking distance (Sokos et al., 2006). Here, GLP1R is linked to heart failure.