Conversely, in male C57BL/6J mice subjected to T2DM via HFD supplementation (45% kcal from lard) for 28-weeks with STZ (90 mg/kg) administered and TAC surgery performed at the 12-week and 18-week time points, respectively, treatment with the DPP-4 inhibitor, MK-0626 (provided in the diet to achieve 3 mg/kg/day), for the final 15-weeks exacerbated cardiac hypertrophy and reduced LVEF (Mulvihill et al., 2016). Here, DPP4 is linked to type 2 diabetes mellitus.