In BON-1 cells, a frequently used model system of pancreatic neuroendocrine tumor (PNET) research, silencing PCSK9 expression by either agomirs of miR-224 or by siRNA directed against PCSK9 increased the rate of apoptosis (Bai et al., 2016). The gene discussed is PCSK9; the disease is primitive neuroectodermal tumor.