SQSTM1 and acute respiratory distress syndrome: Compared with the control group, the abundance of proautophagy proteins (Beclin1, p62, Atg7, Atg5, and LC3II/LC3I) was reduced in APAP-induced ALI in mice, whereas phosphorylation of mTOR at serine 2,448 was upregulated and the protein abundance of these proautophagy proteins was significantly recovered by CD treatment (Figures 7A–F).