The Ace2 enzyme is responsible for converting Ang II to Ang 1–7, which binds to MasR. The Ace2/Ang (1–7)/MasR pathway antagonizes the pro-inflammatory, pro-proliferative, and fibrotic effects induced by the Ace/Ang II/AT1R pathway, and is a novel target for the treatment of hypertension (Jiang et al., 2014). This evidence concerns the gene AGTR1 and hypertensive disorder.