PD led to a significant increase in the production of all analyzed pro-inflammatory cytokines, TNF-α, IL-6, and IL-1β, except for TNF-α in the WPD group, and TELM treatment was able to significantly reduce TNF-α and IL-1β production, only in the STelm + PD group than in the SPD group (Figures 5A,C). Here, TNF is linked to Platelet storage pool disease.