P2RX7 and type 2 diabetes mellitus: On the other hand, when the analysis was performed with BRCA patients who also suffer from T2DM, a significant increase in the expression of P2X7 after chemotherapy in both T2DM and non T2DM (N-T2DM) patients was detected (Supplementary Figure S2C,D), which shows that T2DM has no effect in the regulation of P2X7 expression.