AKT1 and obesity due to melanocortin 4 receptor deficiency: As shown in Figure 4B, the 25 overlapping gene symbols interacted closely with the pathways involved in apoptosis (hsa04210), PI3K-AKT signaling pathway (hsa04151), and MAPK signaling pathway in diabetic complications (hsa04010), suggesting that these pathways may mediate the anti-obesity effects of ZBM.