However, likely due to a down-regulated expression, the microtubule-associated protein-2 (MAP2), a typical dendritic marker, could not immunohistochemically visualize these putative dendritic DNs in human or transgenic AD mouse brains (Zhang et al., 2009; Cai et al., 2010; Takahashi et al., 2013). This evidence concerns the gene MAP2 and Alzheimer disease.