BGLAP and Cognitive impairment: In a recent study, intravenous (IV) injection of plasma derived from OCN+/+ 3 month-old mice rescued cognitive function of 16 month-old WT mice, but this therapeutic effect could not be replicated with OCN−/− mice, suggesting OCN may play a role in mitigating age-related cognitive deficits (Khrimian et al., 2017).