Indeed, a host of miRNAs regulate genes involved in production of amyloid plaques (Jahangard et al., 2020) and hyperphosphorylated tau (Femminella et al., 2015; Moncini et al., 2017), as well as those encoding cytokines canonically associated with chronic neuroinflammation (Ravari et al., 2017; Liu et al., 2019)—most of which are downregulated in the AD brain (Reddy et al., 2017b). This evidence concerns the gene MAPT and Alzheimer disease.