SIRT1, FOXO1, p250GAP || Reduction in miR-132 appears preclude neuron loss; in vitro miR-132 protects neurons against both Aβ and glutamate; In early AD, expression is increased and correlated to higher MMSE scores; In late AD, expression is abrogated in both AD brain and neural exosomes. The gene discussed is FOXO1; the disease is Alzheimer disease.