Prophylactic administration of muAB5, a CSF1R antagonist, significantly reduced production of IL-6, CXCXL8, C-C motif chemokine ligand 2 (CCL2), CCL7, and matrix metalloproteinase 9 (MMP-9) in a collagen-induced arthritis (CIA) mouse model of RA (Garcia et al., 2016). This evidence concerns the gene CCL2 and rheumatoid arthritis.