c-Maf, IFNGR1, SHIP1 || Regulates microglial inflammatory response; Heavily upregulated in 3xTg murine models of AD; elevated levels coincide with c-Jun expression, microglial and astrocyte activation, and upregulated secretion of inflammatory mediators; Has also been implicated in activation of a wide gamut of T lymphocytes. This evidence concerns the gene INPP5D and Alzheimer disease.