MAPT and early-onset autosomal dominant Alzheimer disease: For instance, we hypothesize that the laminar pattern of dissemination of phosphorylated tau protein in Alzheimer’s disease (Arnold et al., 1991; Braak and Del Tredici, 2015) and other tauopathies across neocortical areas will be predicted by cortical type under the rules of the Structural Model (Barbas and Rempel-Clower, 1997; Garcia-Cabezas et al., 2019).