ENO2 and meningeal tuberculosis: In lumbar CSF of children with TBM, S100B and NSE (structural proteins of the CNS, and biomarkers of CNS tissue damage) at disease onset were associated with poor outcome, as was highest concentration overall and an increasing profile over time in S100B, NSE, and GFAP neuromarker concentrations increased over time in those who died (whilst inflammatory markers decreased), and were overall highest in those with cerebral infarction32.