IL6 and breast cancer: Furthermore, IL1-β was shown to promote stem-cell–like phenotypes and invasiveness in MCF7 BC cell through the up-regulation of IL-6 (Oh et al., 2016), which has been shown to be released not only by cancer cells but also by adipocytes, CAFs, and TAMs (Gyamfi et al., 2018; Xu et al., 2019).