In this vein, immunohistochemical studies showed that GPER levels are positively associated with tumor size, distant metastases, and recurrence in BC specimens and inversely correlated with disease-free survival in tamoxifen-treated patients (Filardo et al., 2006; Liu et al., 2009; Ignatov et al., 2011). The gene discussed is GPER1; the disease is neoplasm.