Interestingly, BC cells exposed to conditioned medium from TAMs have been shown to exhibit loss of ERα expression, increase of the proliferative marker Ki67, and the activation of c-Src, PKC, and MAPK transduction pathways, further supporting a role for TAMs in the endocrine resistance and BC patients’ prognosis (Stossi et al., 2012). The gene discussed is MKI67; the disease is breast cancer.