Secreted matrix metallopeptidase-2 (MMP-2) and urokinase-type plasminogen activator surface receptor (uPAR) have been demonstrated to activate focal adhesion kinase (FAK), which acts as an executioner of Bcl-w-dependent invasive phenotype of gastric cancer cells (Bae et al., 2009). The gene discussed is MMP2; the disease is gastric cancer.