Importantly, Rab39b KO mice treated with rapamycin showed significantly improved memory in novel object recognition tests when compared to controls (Figure 5C), while rapamycin treatment had no effect on affecting their locomotor activity in open field tests (Supplementary Figure 7A) or reversing the compromised short-term working memory in T maze tests (Supplementary Figure 7B), and the decreased anxiety in high elevated plus maze tests (Supplementary Figure 7C). The gene discussed is RAB39B; the disease is Anxiety.