INS and colorectal carcinoma: In fact, hyperglycemia (high blood sugar level) and hyperinsulinemia (high insulin level) resulting from high GI-diet could contribute to the initiation or progression of CRC through the induction of DNA damage in colon cells (Othman et al., 2013; Othman et al., 2014), or the action of insulin-like growth factor (Aleksandrova et al., 2013) which has a known role in the pathogenesis and progression of CRC (Vigneri et al., 2015; Kasprzak and Adamek, 2019).