HSF1 and hepatocellular carcinoma: Constitutively activated RAS/MAPK signaling also activates heat shock factor 1 (HSF1), thereby increasing the expression of cholesterol biosynthesis-related genes such as SREBF2, HMGCR, HMGCS1, etc. In contrast, HSF1 inhibition sensitizes HCC cells to the antiproliferative effects of simvastatin (85).