The tumor suppressor gene ARH-I (also known as DIRAS3), which is epigenetically silenced in a vast majority of ovarian cancers, promotes autophagy in cultured OC cells (40, 123), and its inactivation in the context of a xenografted tumor in mice causes the interruption of dormancy and the rapid re-growth of the tumor (124). Here, DIRAS3 is linked to ovarian carcinoma.